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Post Doctorate RA General Neuroproteomics

Company: Pacific Northwest National Laboratory
Location: Richland
Posted on: October 13, 2020

Job Description:

Job Details Full-timeEstimated: $42,000 - $62,000 a year5 hours ago Qualifications - Statistical software - Communication skills - R - Python - Doctoral degree Full Job Description Organization and Job ID Job ID: Directorate: Earth & Biological Sciences Division: Biological Sciences Group: Integrative Omics Job Description A few post-doctoral positions available in Integrative Omics group at PNNL for collaborative project involving Columbia University, Vanderbilt University and Rush Alzheimer's Disease Center. The successful applicants will be immersed into application of proteomics to the research of Alzheimer's disease (AD) and associated pathologies affecting cognition. There is a number of projects to choose from. One project involves profiling post-translational modifications across human brain samples of subjects with AD and controls. The objective of this project is to refine our understanding of the pathologic mechanism and potentially develop drug targets. Another project focuses on validation of nominated drug targets by large-scale (> 1,000 samples) quantitative targeted proteomics (SRM) analysis. The highly quantitative data jointly with rich clinical data enables inference of the role of individual proteins in neurodegeneration by advanced statistical modeling techniques. Third project focuses on small-scale analysis of microglia samples enriched from post-mortem human brains using FACS technique. Finally, forth project aims at development of a method for estimating age and turnover of the beta-amyloid plaques using advanced ion mobility separation technique. These post-doctoral positions provide opportunities to learn a variety of proteomics techniques, the cutting-edge developments in AD research and statistical analysis of omics and clinical data. The latest research along these directions can be learned from the following publications: Details about the proteomics group in general can be learned at the web site: . PNNL provides a highly collaborative environment with opportunities to satisfy broad scientific curiosity and develop a professional network. Minimum Qualifications Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university. Preferred Qualifications Strong organization and communication skills are needed to work efficiently in a team environment and to effectively demonstrate project success. The successful candidate will have a Ph.D. in one of the disciplines: neurobiology, neurology, biochemistry or bioanalytical chemistry. Solid background in statistics and experience with statistical software is required. R or python programming skills is a plus. Equal Employment Opportunity Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at . Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from participation in certain foreign government talent recruitment programs. If you are offered a position at PNNL and are currently a participant in a foreign government talent recruitment program you will be required to disclose this information before your first day of employment. Directorate: Earth & Biological Sciences Job Category: Post-Graduates and Post-Docs Group: Integrative Omics Opening Date: 2020-10-07 Closing Date: 2020-11-06 Show full job description Apply Now

Keywords: Pacific Northwest National Laboratory, Richland , Post Doctorate RA General Neuroproteomics, Other , Richland, Washington

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